Alpha-1 blocker intermediate

2-(2-Ethoxyphenoxy) Ethyl Bromide

Ethoxyphenoxy ethyl bromide — the aryl-ether alkylating agent in the tamsulosin synthesis.

CAS No.: 3259-03-8
Molecular formula: C₁₀H₁₃BrO₂
Mol. weight: 245.11 g/mol
Appearance: Colourless to pale yellow liquid
API target: Tamsulosin hydrochloride (CAS 106133-20-4)

Description

This bromoethyl aryl ether is used to N-alkylate the chiral aminoethyl sulfonamide fragment of tamsulosin, installing the 2-ethoxyphenoxy side chain that confers selectivity for the α1A-adrenergic receptor.

Applications

Tamsulosin hydrochloride final-step alkylation

Other products

4-Chloro Benzophenone

C₁₃H₉ClO

4-Chloro Benzhydrol

C₁₃H₁₁ClO

4-Chloro Benzhydryl Piperazine

C₁₇H₁₉ClN₂

(R)-(4-Chlorophenyl)(phenyl)methanamine

C₁₃H₁₂ClN