Antidepressant intermediate

5-Cyano Indole

1H-Indole-5-carbonitrile

Indole-5-carbonitrile — the aromatic core of vilazodone and several serotonergic agents.

CAS No.: 15861-24-2
Molecular formula: C₉H₆N₂
Mol. weight: 142.16 g/mol
Appearance: White to off-white crystalline solid
API target: Vilazodone hydrochloride (CAS 163521-12-8)

Description

5-Cyano indole is alkylated at C-3 with a 4-halobutyl chain to deliver the advanced vilazodone intermediate. The 5-cyano group is retained throughout the synthesis as part of the final API pharmacophore.

Applications

Vilazodone manufacture
5-HT receptor ligand research

Other products

4-Chloro Benzophenone

C₁₃H₉ClO

4-Chloro Benzhydrol

C₁₃H₁₁ClO

4-Chloro Benzhydryl Piperazine

C₁₇H₁₉ClN₂

(R)-(4-Chlorophenyl)(phenyl)methanamine

C₁₃H₁₂ClN