Chiral antihistamine intermediate

N,N-Bis(2-chloroethyl)-4-methylbenzenesulfonamide

Bis-chloroethyl tosyl sulfonamide used to construct the piperazine ring of levocetirizine.

CAS No.: 42137-88-2
Molecular formula: C₁₁H₁₅Cl₂NO₂S
Mol. weight: 296.21 g/mol
Appearance: White crystalline powder
API target: Levocetirizine dihydrochloride (CAS 130018-87-0)

Description

This reagent is the masked piperazine equivalent in the asymmetric synthesis of levocetirizine. It is cyclised onto chiral benzhydrylamines to deliver enantiopure 1-benzhydrylpiperazine derivatives without racemisation.

Applications

Asymmetric piperazine ring construction
Levocetirizine and cetirizine routes

Other products

4-Chloro Benzophenone

C₁₃H₉ClO

4-Chloro Benzhydrol

C₁₃H₁₁ClO

4-Chloro Benzhydryl Piperazine

C₁₇H₁₉ClN₂

(R)-(4-Chlorophenyl)(phenyl)methanamine

C₁₃H₁₂ClN