Chiral antihistamine intermediate

(–)-p-Chloro Benzhydryl Piperazine

Levo-rotatory benzhydryl piperazine — the chiral penultimate intermediate to levocetirizine.

CAS No.: 130018-88-1
Molecular formula: C₁₇H₁₉ClN₂
Mol. weight: 286.80 g/mol
Appearance: Off-white crystalline solid
API target: Levocetirizine dihydrochloride (CAS 130018-87-0)

Description

The (–)-enantiomer of 4-chloro benzhydryl piperazine carries the correct absolute configuration required for the levocetirizine API. It is N-alkylated with carboxymethoxy ethyl chloride to deliver levocetirizine in high enantiomeric purity.

Applications

Levocetirizine final-step alkylation

Other products

4-Chloro Benzophenone

C₁₃H₉ClO

4-Chloro Benzhydrol

C₁₃H₁₁ClO

4-Chloro Benzhydryl Piperazine

C₁₇H₁₉ClN₂

(R)-(4-Chlorophenyl)(phenyl)methanamine

C₁₃H₁₂ClN